11.   The butyric acid concentration was particularly high in the proximal colon and this has been reported to induce diffrentiation in colonic cancer cell lines.

12.   A reduced fibre content of the diet on its own might be an important contributor to the development of colonic cancer.

13.   One patient died of disseminated colonic cancer after three years, the three previous complete annual colonoscopies had been negative for dysplasia.

14.   Appying these criteria to our results, one of nine colonic cancers that arose in association with ulcerative colitis during the surveillance period was detected by the surveillance programme.

15.   It may be that unsuppressed inflammation, while causing few or no symptoms, places these patients at increased risk of developing colonic cancer.

16.   The final diagnosis in control patients was diverticular disease, colonic cancer, unexplained anaemia, and irritable bowel syndrome.

17.   These patients should, therefore, be fully investigated to exclude the possibility of colonic cancer, in addition to stopping the drugs.