11.   Some of those companies will produce breakthrough drugs and medical products in the coming decades and develop tools that will speed the process of drug discovery.

12.   The find raises the possibility that a breakthrough drug for women might also help men.

13.   The pharmaceutical companies insist that huge research costs justify high prices for breakthrough drugs but they guard their numbers as trade secrets.

14.   At one point a few years ago, doctors thought leptin could be used as a breakthrough obesity drug.

15.   Leaders of the scientific community expressed worries over the campaign and said research on the patent were key to the development of breakthrough drugs.