11.   And to think, NBC and TNT thought their biggest obstacle was going up against the National Football League this fall.

12.   Apparently, the biggest obstacle that scuttled negotiations for the rematch was weight.

13.   As always, raising money may be the biggest obstacle candidates face.

14.   Arizona Republicans and the U.S. Interior Department on Friday removed the two biggest obstacles to keeping the Grand Canyon open if the federal government shuts down again.

15.   As many aspiring home buyers know, to their regret, the biggest obstacle to ownership can often be the down payment.

16.   As with conventional gene therapy, though, delivering the PTMs is the biggest obstacle.

17.   Besides, Joe and Kathleen are their own biggest obstacles, battling ever more fiercely in the real world while their online attraction deepens.

18.   Besides money, however, the biggest obstacle is where to find the perfect junk.

19.   Besides recruiting patients, the biggest obstacle to the studies is cost.

20.   Bioethicists contacted by New Scientist agree that the biggest obstacle is likely to be public acceptance.