91.   Patients showed a marked decrease in bone mineral density after one year, which persisted through clinical studies up to two years, FDA officials said.

92.   PhRMA has a task force on women in clinical studies, and the group will offer comments to the FDA, Oman said.

93.   Phase III is the last of three clinical studies required before seeking Food and Drug Administration approval.

94.   Panel members said, though, that the FDA should review the results of a second clinical study before giving final approval to the drug.

95.   Participation rates for clinical studies are low, analysts agree.

96.   Patients do not have to be enrolled in a clinical study to try it.

97.   Proceeds from the stock sale will be used for research and clinical studies, to repay debt, for marketing and sales and for other working capital needs.

98.   Quigley Corp. shares have soared since April, boosted by a clinical study that says its Cold-Eeze lozenges are effective in treating the common cold.

99.   Practitioners generally do not track such information the way researchers did in the clinical studies that first showed the benefits of the combination therapies.

100.   Researchers also worry that providing drugs outside the carefully controlled clinical studies risks clouding up the investigation, and might ultimately slow approval.