1.   Fistula formation - for example to the trachea - May then be the first sign of the true nature of the disease.

2.   For solar flares, a system of early warning satellites around the Sun could detect the first sign of trouble.

3.   I know some guys who bail out after the first sign of difficulty and easily slip into a new relationship.

4.   Peasant uprisings were the first signs of discontent among the people.

5.   The demonstrators melted away at the first sign of trouble.

6.   The first signs of breeding will probably involve some serious digging activity, often round the bases of the rocks.

7.   The new year saw the first signs of a thaw in that deep freeze.

8.   Therapy should begin when the first signs are noticed.